Vaccine-Associated Feline Sarcoma Task Force: Roundtable Discussion

Feline Roundtable.qxp

T Vaccine-Associated Feline Sarcoma Task Force (VAFSTF) has served veterinarians, cats, and cat owners for nearly nine years. Initially designed to function for only three years, the VAFSTF members found a continuing need to address this issue of utmost importance. Having fulfilled its mission to stimulate research and initiate preliminary changes in vaccination protocols designed to reduce the...

Abrogation of resistance to feline oncornavirus disease by immunization with killed feline leukemia virus.

Four-week-old specific-pathogen-free cats were immunized with a combined vaccine composed of killed feline leukemia virus and killed feline oncornavirus-associated cell membrane antigen-containing tumor cells. Immunization induced feline oncornavirus-associated cell membrane antigen antibody titers ranging from 1:32 to 1:256 but did not elicit detectable virus-neutralizing antibody titers. Kitt...

Feline Vaccine-Associated Sarcomas

Association of germ-line polymorphisms in the feline p53 gene with genetic predisposition to vaccine-associated feline sarcoma.

A case-control study was conducted in order to investigate the association of polymorphisms in the genomic sequence of the feline p53 gene with a predisposition to vaccine-associated feline sarcoma (VAFS). In the study, 50 domestic short hair cats with a confirmed histopathologic diagnosis of VAFS were matched to disease-free controls (1:2) by age, sex, and breed. Cats from both the diseased (c...

WSAVA vaccination guidelines for the dog and the cat.

In 1996, a group of academicians and feline practitioners met in an effort to develop vaccination recommendations for cats. At the time, we were concerned with a series of publications highlighting that, at least in some cats, feline leukaemia and rabies vaccines were causally associated with a particularly aggressive form of fibrosarcoma. If recommendations could be written that were consisten...